Showing posts with label Erastin. Show all posts
Showing posts with label Erastin. Show all posts

Tuesday, May 29, 2012

Ferroptosis, a new type of cell death with potential applications


Ferroptosis, a new type of cell death,  is the iron dependent form of nonaptotic cell death triggered by  the oncogenic  RAS-selective lethal small molecule erastin (Nonapoptotic forms of cell death may facilitate the selective elimination of some tumor cells or be activated in specific pathological states). Ferroptosis is dependent upon intracellular iron, but not other metals, and is morphologically, biochemically, and genetically distinct from