Epigenetic modifications, such as DNA and histone
methylation, are responsible for regulatory pathways that affect disease.
Current epigenetic analyses use bisulfite conversion to identify DNA methylation
and chromatin immunoprecipitation to collect molecules bearing a specific
histone modification. A new method using a nanofluidic device that combines
real-time detection and automated sorting of individual molecules based on
their epigenetic state has been developed by a group of Scientists from Cornell
University.
This device evaluates the
fluorescence from labeled epigenetic modifications
