tssRNA , a new type of transcription start site associated small RNA in bacteria

Researchers from Spain have identified a  new class of small RNA (~45 bases long)  in gram positive and negative bacteria. These tssRNAs are associated with RNA polymerase pausing some 45 bases downstream of the transcription start site and show global changes in expression during the growth cycle.  They are related to eukaryotic tiRNAs in their localization (transcription start sites, TSS) but not in their biogenesis. tssRNAs are generated at the same positions

Light switch for gene expression with potential use in therapeutics

Scientists from  North Carolina State University have identified light-activated molecules to turn gene expression on and off. Triplex-forming oligonucleotides (TFOs) are commonly used molecules that can prevent gene transcription by binding to double-stranded DNA

A light-activated “cage” was attached to a Triplex-forming oligonucleotides. In the absence of light, transcription activity is 100 percent. When exposed to ultraviolet (UV) light, the cage is