Scientists from North Carolina State University have identified light-activated molecules to turn gene expression on and off. Triplex-forming oligonucleotides (TFOs) are commonly used molecules that can prevent gene transcription by binding to double-stranded DNA
A light-activated “cage” was attached to a Triplex-forming oligonucleotides. In the absence of light, transcription activity is 100 percent. When exposed to ultraviolet (UV) light, the cage is
A light-activated “cage” was attached to a Triplex-forming oligonucleotides. In the absence of light, transcription activity is 100 percent. When exposed to ultraviolet (UV) light, the cage is
